Sam De Brouwer

Sam co-founded XY.AI Labs in 2023 with Lamara De Brouwer and runs it today. She sets its thesis: healthcare operations don't need AI that talks, they need AI that executes. Under her the company has moved from a first agent system to an orchestration layer that runs claims, eligibility, prior authorization, payment posting and document workflows in production for providers, payers and health-IT vendors. She has been CEO since February 2025 and a board member since 2023.

She writes most of the company's public thinking, from the case for AI-native operations to what free compute signals about a startup, and represents XY.AI Labs on stage, including the AI Engineer panel with Neo4j.

Sam has built AI and technology companies since the 1990s. She co-founded doc.ai, where she was COO and then CEO, and stayed on as Sharecare's Chief Strategy Officer for four years after it acquired the company in 2021. Before that she co-founded Scanadu, a digital health company with a lab at NASA Ames, and, under the name Samia Lounis, Jobscape, one of Europe's first online employment platforms. She co-founded and curated TEDAI San Francisco, TED's AI chapter, and is a named inventor on two US patents for predicting physiological parameters from images.

Full career history on LinkedIn.